Nicotinamide Riboside Chloride (NR)
The Better Choice for True Cellular Energy.
At Bellevue Skin & Wellness, our goal is to deliver the most effective and comfortable cellular health treatments available. That’s why we now offer IV NR (Nicotinamide Riboside) — a next-generation approach to activating your body’s own NAD+ system.
While IV NAD+ has been popular for years, research and clinical experience now show a better option:
NAD, delivered smarter — that’s NR.
NR is a highly bioavailable vitamin B3 derivative that your body converts directly into NAD+ inside your cells — where energy, repair, and longevity pathways actually happen.
This means higher true NAD+ levels, better tolerability, and better results.
What Is NAD+ and Why Does It Matter?
Two Ways to Boost NAD+: IV NAD+ vs. IV NR
There are two primary infusion methods:
V NAD+ (Direct NAD+)
– Infuses NAD+ directly into the bloodstream
– Poorly absorbed inside cells
– Can cause uncomfortable side effects
– May suppress natural NAD production
IV NR (Nicotinamide Riboside)
– A highly absorbable NAD+ precursor
– Easily enters the cell
– Converts instantly into NAD+ through the NRK pathway
– Supports natural NAD production
– Much more comfortable for patients
Experience the full-body impact of cellular restoration.
Higher NAD+ Levels Inside the Cell
NAD+ works inside your mitochondria — yet IV NAD+ has difficulty entering the cell.
NR slips through easily and transforms into NAD+ exactly where it’s needed.
Outcome: Better energy, better repair, better longevity.
Faster and More Efficient Conversion
NR follows the body’s natural high-speed pathway:
NR → NMN → NAD+
This pathway is highly active in:
Brain
Muscles
Heart
Liver
Outcome: Smooth, steady energy and enhanced cellular performance.
Significantly Fewer Side Effects
IV NAD+ can trigger:
Nausea
Chest tightness
Abdominal pressure
Headache
Anxiety
These occur because NAD+ pools outside cells.
NR avoids this entirely by converting inside the cell.
Outcome: A much more comfortable infusion experience.
Better Support for Anti-Aging & Longevity Pathways
NAD+ is required for:
DNA repair
Sirtuin activation (SIRT1, SIRT3, SIRT6)
Metabolic regulation
Mitochondrial renewal
Because NR reliably increases intracellular NAD+, it more strongly activates these pathways.
Outcome: Better aging support, improved metabolism, and enhanced cellular resilience.
Supports — Not Suppresses — Your Natural NAD System
High-dose IV NAD+ may cause your body to reduce its own NAD production.
NR gently enhances natural NAD creation rather than shutting it down.
Outcome: More sustainable, long-term NAD improvement.
Common questions about our treatment.
What does NR stand for?
NR stands for Nicotinamide Riboside, a form of vitamin B3 and a precursor your body uses to make NAD+.
How is IV NR different from IV NAD+?
IV NR easily enters cells; NAD+ does not
NR converts into NAD+ through the fastest natural pathway
NR causes fewer side effects
NR increases NAD+ levels where your cells can actually use it
Is IV NR safer or more comfortable?
Yes. Patients usually tolerate IV NR extremely well.
Most report a smooth, relaxing infusion without the discomfort often associated with IV NAD+.
How long does an IV NR infusion take?
Typically 30–45 minutes, depending on your dose and comfort.
How soon will I feel results?
Many patients report:
Improved mental clarity
More stable energy
Better sleep quality
Faster recovery
within 24–48 hours.
How often should I get IV NR?
Most patients receive:
Weekly during an optimization phase
Monthly for maintenance
Customized protocols are available based on goals
Can IV NR support anti-aging?
Yes. By boosting NAD+ inside the cell, NR directly supports:
DNA repair
Sirtuins
Mitochondrial function
Metabolic health
All essential longevity pathways.
Is IV NR right for everyone?
Most adults can benefit from NR, but it is especially useful for those with:
Fatigue
High stress
Aging-related concerns
Athletic recovery needs
Chronic inflammation
Metabolic slowdown
Mitochondrial weakness
A consultation can determine the best protocol for your goals.